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You see this is an appeal for you to join www.find-a-drug.co.uk You might have heard about SETI@home, you know the thing where a program runs in the background using your unused processing power to scan data from a satellite dish.
Well FAD is similar in operation, except that instead of looking for aliens it looks for molecules and proteins that can be targeted for further research and stuff in finding a cure for cancer.
I have been running distributed computing projects for over a year now.
It doesn't require much effort, you download a small program and a work unit (WU). Then the program runs in the background just processing. When it finishes that WU it moves on to the next in the queue of 2 or 3 that you download every so often from the net. When it is finished it gets sent back to FAD.
The program doesn't cause slowdown, it only uses unused power, as whenever you do anything else like type a letter it lets you do that and then starts processing again. After all other than in video editing or really high powered games you only ever use an average of 10% or so of your computers capacity. So why don't you donate it to a good cause?
FAD has several ongoing projects. Currently these are cancer, HIV, malaria, multiple sclerosis, SARS and bio terrorism antidotes.
If you do decide to join, I have now created a Special Reserve team. The team number for entering on the setup screen is 2072. So come on join up. So far there is 13 of us in the team. Out of 147 teams, Special Reserve is ranked 54. There is even a linux version now.
One day our efforts could make a difference. Imagine the lives that could be saved. In Britain, 1 in 3 people get cancer. Over a million people a year die in developing countries from Malaria, 3 times as many as AIDS kills. Even so, HIV is at epidemic levels and kills 100,000s a year all around the world. 40 million people in Africa have HIV, and in time it will kill them all.
This project doesn't require anything much of you, all you have to do run the program in the background. You can help to make a difference. It all builds up, just from lots of people running this. So far nearly 4,000 years worth of computer time has been spent scanning 27.62 billion moleculules.
There have been successes in finding growth inhibitors on several occasions in several areas. So come on, join us and help save the world.
Well FAD is similar in operation, except that instead of looking for aliens it looks for molecules and proteins that can be targeted for further research and stuff in finding a cure for cancer.
I have been running distributed computing projects for over a year now.
It doesn't require much effort, you download a small program and a work unit (WU). Then the program runs in the background just processing. When it finishes that WU it moves on to the next in the queue of 2 or 3 that you download every so often from the net. When it is finished it gets sent back to FAD.
The program doesn't cause slowdown, it only uses unused power, as whenever you do anything else like type a letter it lets you do that and then starts processing again. After all other than in video editing or really high powered games you only ever use an average of 10% or so of your computers capacity. So why don't you donate it to a good cause?
FAD has several ongoing projects. Currently these are cancer, HIV, malaria, multiple sclerosis, SARS and bio terrorism antidotes.
If you do decide to join, I have now created a Special Reserve team. The team number for entering on the setup screen is 2072. So come on join up. So far there is 13 of us in the team. Out of 147 teams, Special Reserve is ranked 54. There is even a linux version now.
One day our efforts could make a difference. Imagine the lives that could be saved. In Britain, 1 in 3 people get cancer. Over a million people a year die in developing countries from Malaria, 3 times as many as AIDS kills. Even so, HIV is at epidemic levels and kills 100,000s a year all around the world. 40 million people in Africa have HIV, and in time it will kill them all.
This project doesn't require anything much of you, all you have to do run the program in the background. You can help to make a difference. It all builds up, just from lots of people running this. So far nearly 4,000 years worth of computer time has been spent scanning 27.62 billion moleculules.
There have been successes in finding growth inhibitors on several occasions in several areas. So come on, join us and help save the world.
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Quick update.
The current Malaria query has now finished.
There is now a new query in the respiratory diseases section, 1G3U-Q1, which is for TB.
"This kinase converts thymidine monophosphate (TMP) to the di- and tri-phosphates. Inhibiting this process would be expected to significantly disrupt the cell cycle (ie growth). There is sufficient variation from the mammalian form and that found in mycobacterium tuberculosis to give scope for selective inhibition."
HIV is still running.
"Protease inhibition is established as a key therapeutic approach limiting the progress of HIV. However, mutations of the virus protein have the consequence that resistance develops. This is one of a series of possible queries for HIV-1 protease which explore possible modes of inhibition with the view to finding novel inhibitors which are less susceptible to protein mutations. This query has been derived from 1a30-q1 using some initial experimental results indicating activity."
Cancer is still running, with two queries at the moment as one is due to finish soon.
Methodology is still running.
"The small family of cytochrome P450s play an essential role in the metabolism of certain drug molecules by converting them to more soluble analogues enabling them to be excreted. In general, drugs that a rapidly metabolised and excreted need to be used in higher doses while molecules than inhibit P450s may cause side-effects or unexpected complications when used with other drug molecules."
There was a new Proteome query which was thought to be useful in the treatment of osteoporosis. However it was a short query and is already finished.
Total project stats:
Jobs 1,892,348
Hits 65,649,482
Molecules 19,479,814,837
Days 874,299
The current Malaria query has now finished.
There is now a new query in the respiratory diseases section, 1G3U-Q1, which is for TB.
"This kinase converts thymidine monophosphate (TMP) to the di- and tri-phosphates. Inhibiting this process would be expected to significantly disrupt the cell cycle (ie growth). There is sufficient variation from the mammalian form and that found in mycobacterium tuberculosis to give scope for selective inhibition."
HIV is still running.
"Protease inhibition is established as a key therapeutic approach limiting the progress of HIV. However, mutations of the virus protein have the consequence that resistance develops. This is one of a series of possible queries for HIV-1 protease which explore possible modes of inhibition with the view to finding novel inhibitors which are less susceptible to protein mutations. This query has been derived from 1a30-q1 using some initial experimental results indicating activity."
Cancer is still running, with two queries at the moment as one is due to finish soon.
Methodology is still running.
"The small family of cytochrome P450s play an essential role in the metabolism of certain drug molecules by converting them to more soluble analogues enabling them to be excreted. In general, drugs that a rapidly metabolised and excreted need to be used in higher doses while molecules than inhibit P450s may cause side-effects or unexpected complications when used with other drug molecules."
There was a new Proteome query which was thought to be useful in the treatment of osteoporosis. However it was a short query and is already finished.
Total project stats:
Jobs 1,892,348
Hits 65,649,482
Molecules 19,479,814,837
Days 874,299
They've now done a bit of a redesign to the stats and stuff. Instead of points we now have gigaflops.
New project started today. Malaria.
"In Plasmodium falciparum (the parasite which causes Malaria), Enoyl Reductase (ENR) [That is the protein - Biggles] plays a critical role creating long chain molecules known as fatty acids which are used in the synthesis of cell wall mycolic acids. Effective inhibition of this enzyme has been demonstrated to have therapeutic potential in the treatment of Malaria.
Inhibiting Enoyl Reductase in Mycobacterium tuberculosis would also be effective against drug resistant strains of TB."
Just to let you all know. Haven't run one yet, don't know how long they'll take.
They did a press release as well. [URL]http://www.find-a-drug.org/press9.html[/URL].
"In Plasmodium falciparum (the parasite which causes Malaria), Enoyl Reductase (ENR) [That is the protein - Biggles] plays a critical role creating long chain molecules known as fatty acids which are used in the synthesis of cell wall mycolic acids. Effective inhibition of this enzyme has been demonstrated to have therapeutic potential in the treatment of Malaria.
Inhibiting Enoyl Reductase in Mycobacterium tuberculosis would also be effective against drug resistant strains of TB."
Just to let you all know. Haven't run one yet, don't know how long they'll take.
They did a press release as well. [URL]http://www.find-a-drug.org/press9.html[/URL].
Didnt know that this FAD is done by a local company near where I live.
More success. HIV inhibitors have been found. [URL]http://www.find-a-drug.org/press8.html[/URL].
You sure it was FAD? I've never had any problems with it under any set up I've tried it on. It being more stable than UD was part of the reason I moved.
What sort of things are we talking about?
What sort of things are we talking about?
Oops. Had to take FAD off again - was doing all sorts of weird things to my Explorer, both Windows and Internet.
Oh well.
Oh well.
Notorious Biggles wrote:
> Your stats show up with all the other team members.
Oh. I knew that..
> Your stats show up with all the other team members.
Oh. I knew that..
Thought they did.
I've got both running now, anyway.
I've got both running now, anyway.
Ortega: there are two ways of doing this. The first is to just install it on his machine and use the same email address when you set it up. It will give different member numbers but all run to the same stats. I did this when changing PCs.
The other way is to put a link to tray.exe in the startup folder of his PC, and have it start up a copy of your tray. This way you only have the one server to deal with. I did this with my infrequently used laptop.
Wookie: yes UD used to use THINK in the past. However it now uses Ligandfit which is actually slower in operation now that THINK has had various optimisations done to the guts of the program by Intel. I notice this a lot, I used to manage only a WU a day or two with UD and now I manage more than that with FAD, despite testing more molecules.
The other way is to put a link to tray.exe in the startup folder of his PC, and have it start up a copy of your tray. This way you only have the one server to deal with. I did this with my infrequently used laptop.
Wookie: yes UD used to use THINK in the past. However it now uses Ligandfit which is actually slower in operation now that THINK has had various optimisations done to the guts of the program by Intel. I notice this a lot, I used to manage only a WU a day or two with UD and now I manage more than that with FAD, despite testing more molecules.
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