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"Help save the world."

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Sat 30/08/03 at 03:34
"I love yo... lamp."
Posts: 19,577
You see this is an appeal for you to join www.find-a-drug.co.uk You might have heard about SETI@home, you know the thing where a program runs in the background using your unused processing power to scan data from a satellite dish.

Well FAD is similar in operation, except that instead of looking for aliens it looks for molecules and proteins that can be targeted for further research and stuff in finding a cure for cancer.

I have been running distributed computing projects for over a year now.
It doesn't require much effort, you download a small program and a work unit (WU). Then the program runs in the background just processing. When it finishes that WU it moves on to the next in the queue of 2 or 3 that you download every so often from the net. When it is finished it gets sent back to FAD.

The program doesn't cause slowdown, it only uses unused power, as whenever you do anything else like type a letter it lets you do that and then starts processing again. After all other than in video editing or really high powered games you only ever use an average of 10% or so of your computers capacity. So why don't you donate it to a good cause?

FAD has several ongoing projects. Currently these are cancer, HIV, malaria, multiple sclerosis, SARS and bio terrorism antidotes.

If you do decide to join, I have now created a Special Reserve team. The team number for entering on the setup screen is 2072. So come on join up. So far there is 13 of us in the team. Out of 147 teams, Special Reserve is ranked 54. There is even a linux version now.

One day our efforts could make a difference. Imagine the lives that could be saved. In Britain, 1 in 3 people get cancer. Over a million people a year die in developing countries from Malaria, 3 times as many as AIDS kills. Even so, HIV is at epidemic levels and kills 100,000s a year all around the world. 40 million people in Africa have HIV, and in time it will kill them all.

This project doesn't require anything much of you, all you have to do run the program in the background. You can help to make a difference. It all builds up, just from lots of people running this. So far nearly 4,000 years worth of computer time has been spent scanning 27.62 billion moleculules.

There have been successes in finding growth inhibitors on several occasions in several areas. So come on, join us and help save the world.
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Tue 31/08/04 at 08:25
Regular
"\\"
Posts: 9,631
Notorious Biggles wrote:
> Time for the monthly pop.
>
> As those of you who run it will probably know by now, the latest
> version of THINK is now it. It should have automatically updated
> itself. There have been a bunch of changes, and there are some more
> sophisticated targets that can now be run. The CPU rating has also
> been tweaked.

Humm. I never noticed that.

> VenomByte, Ortega and AOE should all have certificates now for number
> of molecules run.

Woo.
Tue 31/08/04 at 04:29
"I love yo... lamp."
Posts: 19,577
Time for the monthly pop.

As those of you who run it will probably know by now, the latest version of THINK is now it. It should have automatically updated itself. There have been a bunch of changes, and there are some more sophisticated targets that can now be run. The CPU rating has also been tweaked.

VenomByte, Ortega and AOE should all have certificates now for number of molecules run.

Current targets include 3 different cancer targets, an HIV target and a Proteome one, which is suggested to have uses in the treatment of neurodegenerative diseases, type 2 diabetes and cancer.

In answer to your question FF, what happens is that you have a target. This will be a protein, say a cancer one. Now certain molecules will bind, or attach, to that protein. Most won't. Those that would attach are the "hits" in the software.

Because a bunch of chemical rules are known, you can have a program that works out what molecules will bind to a particular target. Basically if a molecule is a certain shape it will bind, otherwise it won't. Just there are billions of molecules out there and they don't know what ones will bind unless they test them somehow.

What then happens is that you are left with a bunch of molecules that would bind to the target protein. Depending on what these molecules are composed of they may kill the target protein, or inhibit its growth or whatever.

It really is a try until you find one that fits approach, but has generated huge amounts of data and has found hits that have actually shown anti cancer properties when tested for real (as opposed to on a computer) in a lab.

As for your question WoopWoop, email them and they set it up.
Thu 22/07/04 at 11:53
Regular
"I dnt hv a cachfras"
Posts: 481
How do you create a team, I want to set one up for a group of my mates.
Thu 22/07/04 at 09:47
Regular
"RIP: Brian Clough"
Posts: 10,491
Notorious Biggles wrote:
> You don't get what exactly Forest Fan?

What goes on. How does it find cures to diseases?
Thu 22/07/04 at 02:15
"I love yo... lamp."
Posts: 19,577
After installing it, at the FAD setup box where you pick the projects, untick Beta. It is enabled by default although they're going to fix it for the next release. So you might have ended up running the Beta version, which would explain the screwing up.
Wed 21/07/04 at 23:39
Regular
"gsybe you!"
Posts: 18,825
I installed this, but it kept on mucking up.

I'll try it on my faster broadband PC.
Wed 21/07/04 at 23:28
Regular
"\\"
Posts: 9,631
I'm 6th in SR... I'm happy.
Wed 21/07/04 at 17:56
Regular
"Which one's pink?"
Posts: 12,152
I started this when the SR team thing was started, but then eventually stopped doing it.

I did enjoy looking at the funky cool 3d molecules and stuff though.

I'll probably get round to reinstalling it, as it is indeed a damn good thing.
Wed 21/07/04 at 17:51
Regular
"Led Zeppelin"
Posts: 3,214
OUCH!
Wed 21/07/04 at 16:02
"I love yo... lamp."
Posts: 19,577
You don't get what exactly Forest Fan?
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