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"manually removing spyware: any suggestions?"

Right my computer has been badly affected by Spy ware and Ive tried alot of the free SPyware remover programmes however none of them have succesfully removed it.

I think I might have more luck if I manually go in to the msconfig and regedit programmes and try to delete it from there. i dont have a clue what to look for or how to do it though and I was wonderng if anyone knows any sites with good advice or who have any personal help they could give me...

Odd, tried removing the partition and recreating it, I've never come across anything that can't be removed via a simple format.