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I love playing Madden games and out of any sports titles, American Football or otherwise, I think Madden is one of the most polished, complete sports games you can get.
As far as tactics go, I tend to run with the ball a lot rather than throw the ball most of the time. Its always rewarding when you manage to dodge a few players and score a touchdown. ;-)
I like the inclusion of Madden cards as they give you something extra to get. Then of course you can make your own team and playbook, etc.
This is the type of sports game that can last for months, even years. :-)
Plus it eases beginners in too. So theres no reason to feel intimidated if you don't understand how it all works.
Plus if anyone needs help on the rules, I'll always do my best to help them out. ;-)