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I would have :-
A bazooka from the original Medal of Honour
Ice beam from Super Metroid
Displacer from half- Life
There are too much to mention, so just follow this link for some examples of what I mean.
http://gunshop.clandeadgoat.net/
They both rule.
Best gun in any game...EVER. Gimme teh Halo version, cuz it has pretty patterns on the end.
And, if I had to choose one from a film, I'd say the Noisy Cricket from Men in Black!