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Colin, 42, has played M's right-hand man in the last three Bond films and could be the first black 007.
A Ladbrokes spokesman said: "In the past 24 hours we have had a number of inquiries about Colin Salmon being the next Bond.
"We have been forced to close the book for the time being," he told The Sun.
He added: "In a one-hour period on Tuesday afternoon we took six bets of up to #500 each which are huge sums for what is really a novelty wager.
"Three people opened new accounts with us to place the bets. The usual wagers on this type of thing are #10 and #20.
"We are inclined to believe there is something fishy going on and there are spies out there who know more than we do."
The identity of the new Bond has been shrouded in secrecy and various names including Dougray Scott, Ewan McGregor and Colin Farrell are all in the frame.
The role has previously been played by Sean Connery, George Lazenby, Roger Moore, Timothy Dalton and Pierce Brosnan.
WHOOOO!!!
POWER TO THE PEOPLE!
> But not him, he's mildly overweight and not really that attractive. He
> looks too much like Howard from the Halifax ads.
He's hardly even mildly overweight...But I wouldn't want him as Bond, because it would undermine his role as Charles Robinson in the last 3-4 Bond films.
> How does that work? Just because I'm a bloke doesn't mean I don't
> know when another bloke is attractive.
I was joking, and it was nothing personal, sorry.
> How does that work? Just because I'm a bloke doesn't mean I don't
> know when another bloke is attractive.
Look, I'm not sleeping with you and that's the end of it.
> English_Bloke wrote:
> But not him, he's mildly overweight and not really that attractive.
>
> But your a bloke, so your opinion on whether hes attractive or not
> means nothing.
How does that work? Just because I'm a bloke doesn't mean I don't know when another bloke is attractive.